Isosorbide
- Product Name
- Isosorbide
- CAS No.
- 652-67-5
- Chemical Name
- Isosorbide
- Synonyms
- (3R,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diol;at101;IsMotic;Isosorbide (75% solution, 1 g);ucitoL;isobide;hydronol;Isosorbid;NSC 40725;devicoran
- CBNumber
- CB1162705
- Molecular Formula
- C6H10O4
- Formula Weight
- 146.14
- MOL File
- 652-67-5.mol
Isosorbide Property
- Melting point:
- 60-63 °C (lit.)
- alpha
- 42 º (c=3, H2O)
- Boiling point:
- 175°C/2mmHg(lit.)
- Density
- 1.0945 (rough estimate)
- vapor pressure
- 0.007Pa at 20℃
- refractive index
- 45 ° (C=5, H2O)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Crystals, Crystalline Solid or Mass
- pka
- 13.17±0.40(Predicted)
- color
- Off-white to light yellow or beige
- optical activity
- [α]20/D +45.2°, c = 3 in H2O
- Water Solubility
- Soluble in alcohols, water and ketones.
- Sensitive
- Hygroscopic
- Merck
- 14,5224
- BRN
- 80510
- InChIKey
- KLDXJTOLSGUMSJ-JGWLITMVSA-N
- LogP
- -1.39 at 20℃
- CAS DataBase Reference
- 652-67-5(CAS DataBase Reference)
- EPA Substance Registry System
- D-Glucitol, 1,4:3,6-dianhydro- (652-67-5)
Safety
- Risk Statements
- 22
- Safety Statements
- 24/25
- WGK Germany
- 2
- RTECS
- LZ4380000
- TSCA
- Yes
- HS Code
- 29349990
- Hazardous Substances Data
- 652-67-5(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
N-Bromosuccinimide Price
- Product number
- 329207
- Product name
- Dianhydro-D-glucitol
- Purity
- 98%
- Packaging
- 100g
- Price
- $91.5
- Updated
- 2024/03/01
- Product number
- 1352008
- Product name
- Isosorbide
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 1g
- Price
- $436
- Updated
- 2024/03/01
- Product number
- I0407
- Product name
- Isosorbide
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $28
- Updated
- 2024/03/01
- Product number
- I0407
- Product name
- Isosorbide
- Purity
- >98.0%(GC)
- Packaging
- 100g
- Price
- $54
- Updated
- 2024/03/01
- Product number
- A13989
- Product name
- D-Isosorbide, 98%
- Packaging
- 50g
- Price
- $39.3
- Updated
- 2024/03/01
Isosorbide Chemical Properties,Usage,Production
Chemical Properties
off-white to light yellow or beige crystals,
Uses
pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives; the nitrate esters find use as vasodilators and coronary disease therapeutics.
Uses
D-Isosorbide is used as a reagent in the preparation of detergents, agrochemicals, cleansers, cosmetics and vasodilators. It is also employed as a pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives, which is used as vasodilators and coronary disease therapeutics. It is used in the treatment of hydrocephalus and glaucoma. It finds application as a building block for polymers like polycarbonates and polyesters.
Uses
Isosorbide is a reagent widely used to prepare detergents, cleansers, cosmetics, agrochemicals and vasodilators.
Definition
A polyol with a hydroxyl group attached to each of two cis-oriented saturated furan rings. Intermediate for pharmaceuticals. Combustible.
brand name
Ismotic (Alcon).
Biological Functions
emergency treatment of acute angle-closure glaucoma. It should not be confused with isosorbide dinitrate, an antianginal drug.
Flammability and Explosibility
Non flammable
Clinical Use
Isosorbide is basically a bicyclic form of sorbitol that is used orally to cause a reduction in intraocular pressure in glaucoma cases. Although a diuretic effect is noted, its ophthalmologic properties are its primary value.
Isosorbide Preparation Products And Raw materials
Raw materials
Preparation Products
View Lastest Price from Isosorbide manufacturers
- Product
- Isosorbide 652-67-5
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08
- Product
- Isosorbide 652-67-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-06
- Product
- Isosorbide 652-67-5
- Price
- US $7.50-7.00/kg
- Min. Order
- 25kg
- Purity
- 98.5
- Supply Ability
- 300tons
- Release date
- 2023-08-09